Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

The company’s head of oncology, Dave Fredrickson, said the approval of Truqap “reinforces the important role of the PI3K/AKT pathway in HR-positive breast cancer and the critical need to test ...

Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in prostate cancer. Although the most common mutation, in a gene called Pten, ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...