By the early 1990s, the amyloid cascade hypothesis had emerged, proposing that AD is fundamentally caused by deposition of Aβ protein. The cascade component of the hypothesis captures the idea ...

NFTs, which are composed of misfolded tau proteins, represent a key outcome of a dynamic process, much like Aβ plaques are the outcome of the amyloid cascade. However, the question of whether Aβ ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.

Yet despite decades of research, no treatment has been created that arrests Alzheimer’s cognitive deterioration, let alone ...

In 1991 John Hardy, a neuroscientist now at University College, London, and his late colleague David Allsop (then at Queen’s University, Belfast) thus proposed the amyloid cascade hypothesis.

A comprehensive study of brain scans from more than 600 people has shed new light on the relationship between tau protein and ...

challenges long-held assumptions about Alzheimer’s disease treatment. Researchers at the University of Cincinnati found that new monoclonal antibody drugs may slow cognitive decline by ...