Several mutations affecting β-amyloid, either to APP 1,2,3 or to presenilins 4,5, are capable of producing familial forms of AD 6,7,8,9,10,11,12. APP 695 SWE mice expressing transgenic human APP ...

Alzheimer’s disease is likely caused by stalled protein processing in the brain, according to a new study. The research, published today as a Reviewed Preprint in eLife, is described by editors as a ...