Amyl Therapeutics, headquartered in Liège, Belgium, is developing a novel anti-amyloid protein therapeutic that binds to a common structural feature of amyloids, the cross-β amyloid fold ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.

People with diabetes have a higher risk of developing Alzheimer's disease (AD) raising a possible link between the cells that ...

Several mutations affecting β-amyloid, either to APP 1,2,3 ... including the hippocampus. LTP is a model of such use-dependent enhancement in synaptic efficacy, and can be induced by activating ...

A comprehensive study of brain scans from more than 600 people has shed new light on the relationship between tau protein and ...

It turns out that a protein we’ve been fighting against might actually be our brain’s best friend. For years, doctors blamed amyloid beta buildup in the brain for causing Alzheimer’s disease.

These structures result in highly damaging protein aggregations ... can be screened with the worm model. It only takes one ...

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

Amyloidosis develops from a bone marrow disorder. It occurs when an abnormal protein, called amyloid, builds up and forms deposits in the body. Amyloidosis is closely linked to MM. Amyloid light ...

Cutting-edge fluorescent cholesterol probes now enable scientists to visualize cholesterol movement and distribution in live ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...