Several mutations affecting β-amyloid, either to APP 1,2,3 or to presenilins 4,5, are capable of producing familial forms of AD 6,7,8,9,10,11,12. APP 695 SWE mice expressing transgenic human APP ...

The beta amyloid peptide (Abeta) is the primary component of the senile plaques observed ... Our current studies center around our characterization of a variant Abeta peptide that has a single amino ...

Oligodendrocytes are an important source of amyloid beta (Aβ ... Accumulation of Aβ – peptides consisting of 36 to 43 amino acids – is an early critical hallmark of the disease.

Mice deficient in BACE1 (beta-site APP cleaving enzyme 1 ... BACE1 −/− mice also hemizygous for an amyloid precursor protein (APP) transgene lack brain β-amyloid (Aβ) and β-secretase ...

elegans and Protect against Amyloid-β Toxicity in an Alzheimer ... polyunsaturated fatty acids (PUFAs), and essential amino ...