“This decision is an important next step of our collaboration with Denali […] that aims to advance the next generation of [amyloid beta] immunotherapies for the treatment of Alzheimer’s ...
Mice deficient in BACE1 (beta-site APP cleaving enzyme 1 ... BACE1 −/− mice also hemizygous for an amyloid precursor protein (APP) transgene lack brain β-amyloid (Aβ) and β-secretase ...
With the first amyloid-targeting drug now approved for ... developing Alzheimer’s dementia with fewer doses than the first generation of antibody-based amyloid therapies. Moreover, it is also ...