Apolipoprotein E (apoE) is involved in cholesterol metabolism. In humans, there are three major isoforms, E2, E3, and E4. Compared to E3, E4 increases ACD and AD risk and vulnerability to the ...

GOALS We propose to determine the effects of different forms of apoE on the development of induced pluripotent stem (iPS) cells into functional neurons. In Aim 1, iPS cells will be generated from skin ...

METHODS A representative sample of 85 year old people (303 non-demented, 109 demented) were given a neuropsychiatric and a medical examination and head CT. The apoE isoforms were determined. Dementia ...

The mechanism whereby the fragments are generated, escape the secretory pathway, and enter the cytosol has been defined. 4. Determination of the structure and function of the apoE isoforms. The ...

Results: Over a median 5.6 year follow up, Alzheimer’s disease was diagnosed in 206 subjects. Compared with APOE ε3/ε3 genotype, the relative risk (RR) of Alzheimer’s disease was 1.4 (95% confidence ...

Baker-Nigh is a neuroscientist with a research background in neurodegenerative disease, particularly Alzheimer’s disease (AD). Her work in the area has included quantitation of Apolipoprotein E ...