The study will use the ApoE-knockout mouse model, in which deficiency of ApoE leads to development of hypercholesterolemia. We hypothesise that ApoE-KO mice fed on a high fat diet, in comparison to ...

Apolipoprotein E knockout (ApoE −/−) C57BL/6J mice, fed a high-fat diet and subjected to left carotid artery ligation with cannula insertion, received taurine or saline for four consecutive days.