All humans have APOE protein in their genetic makeup, and the main forms, called alleles, are ε2, ε3 or ε4. Each person inherits two APOE alleles—one from each parent—resulting in one of ...

In diabetes, hyperglycemia drives nonenzymatic glycation and oxidation of proteins and lipids ... Here, we studied mice deficient in apolipoprotein E (apoE-null)(refs. 16,17); in these mice ...

Overall, this study will provide comprehensive insights into the structure of apoE proteins and lipidated apoE, guiding the process and formulation development of recombinant apoE products.

including ApoE. Such drug-effects could influence myelin maintenance, synaptogenesis and drug-induced metabolic disturbances. Since our data are obtained in cultured cells, further research is ...