Lewy body dementia (LBD), including dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is one of the most common causes of dementia after AD. The APOE4 allele, the strongest ...

APOE is a key component of amyloid plaques but can also inactivate microglia by binding to a LILRB4 receptor found on the ...

Hematopoietic stem cells have the ability to produce all types of blood cells, but lack receptors for erythropoietin ... VLDL ...

ApoE-null mice developed increased levels of ... such as macrophage scavenger receptor, which was recently implicated in the pathogenesis of atherosclerosis in nondiabetic animals 32,33.

Vigil Neuroscience reported a strong safety profile and 50% sTREM2 reduction in an early-stage trial for VG-3927, potentially ...

and the complement component receptor 1 gene (one study, 544 participants). There were insufficient data to draw conclusions from 24 studies (∼200 participants) of APOE and hereditary CAA or familial ...