(Image: Doudna Lab, UC Berkeley) In the CRISPR-Cas9 system, the guide RNA directs the Cas9 ... either by non-homologous end joining (NHEJ) or homology-directed repair (HDR). NHEJ can result in small ...
(B, C) Confocal microscopic images of coronal brain sections of the hippocampus of Cas9 mice, showing the EGFP ... Single AAV Systems for HDR-Mediated Genome Editing in Vivo Dual AAV Systems ...
AZoLifeSciences on MSN6mon
Applications of Gene Knockout and Knock-in Models in Disease Researchand the Cas9 protein, which induces a DNA double-strand break (DSB) 2. Nuclease-induced DNA DSBs can be repaired through ...
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