(D) Based on the results of cyclin and CDK-knockout studies, scientists have constructed a new threshold model of cell cycle control. Accordingly, either CDK1 or CDK2 bound to cyclin A is ...

Cell cycle events are controlled tightly by several kinase families including CDKs, Plks, and Aurora kinases. What is interesting about these kinases is that they don't always act alone.

"This paper describes the identification and characterization of the first human gene encoding a protein- p21Cip1-which functions to negatively regulate Cdks controlling cell-cycle entry," remarks ...

Cdks and cyclins form complexes whose intrinsic kinase activities enable cell-cycle transitions at G1/S and G2/M. Kaldis' team generated Cdk2/Cdk4 double knockout mice, which die at embryonic day 15 ...

Cyclins regulate steroid receptor action in cyclin-dependent kinase (CDK)-dependent and independent manners. In addition to regulating the cell cycle, cyclin A2 (CCNA2) also mediates female sex ...

Cyclin-dependent kinase enzymes (CDKs) are of two types: cell cycle-regulating CDKs that participate in the progression of the cell cycle and transcriptional ones that control gene expression.