Could all this mean that 'true' (LIF/BMP-dependent) human ES cells have been missed simply because they are much harder to derive than nodal/FGF-dependent epiblast lines? Conditions now routinely ...

A cell lineage is the developmental history of ... factor GABPA as a regulator of zygotic genome activation, epiblast formation and naive pluripotency establishment.

As division continues, some cells divide into the growing mass, distinguishing cells that form the embryo (epiblast) from those that form the placenta (trophectoderm). Further cell divisions lead to ...

At this point, the head develops from the inner cell layer of the cup, the epiblast, and the tail develops on the opposite side. It was previously assumed that this process is triggered and ...

During embryonic stem cell (ESC) development, pluripotent stem cells transition from a naïve state ... While monitoring the ESC-based embryo model’s growth for important structures, they captured an ...