$52 million project called the Knockout Mouse Project (KOMP). Together with the Texas A&M Institute of Genomic Medicine (TIGM), the North American Conditional Mouse Mutagenesis Project (NorCOMM ...

Figure 1: Large-scale strategy for mutagenesis of the mouse genome: a conditional knockout vector is created for each gene and introduced into mouse embryonic stem (ES) cells. The mechanisms ...

To study how microglia fit in, Dinkel and her colleagues created a myeloid-specific Npc1 knockout mouse line. Unlike mice that completely lack Npc1, which die young and have fast-progressing ...

We have observed implantation defects and thus, reduced fecundity in conditional knockout mice models of the autophagy-related proteins in the reproductive tract. In the absence of these proteins, we ...

We have applied both conventional and conditional knockout mouse models of genes specifically involved in folate metabolism and transport (e.g., Folr1, Folr2, Folr4, Rfc1, Slc25a32, Mthfr and Pcft) to ...