Most, but not all, CpG dinucleotides are methylated in the genomic DNA of vertebrates. Spontaneous deamination of 5-methyl-cytosines can escape detection by the DNA repair system, which makes ...

Cells employ an arsenal of editing mechanisms to correct mistakes made during DNA replication. How do they work, and what happens when these systems fail?

deamination, is about twice as likely to happen when a cytosine is chemically tagged by the addition of a molecule known as a methyl group to create 5-methylcytosine, which occurs in DNA at so ...

Mutations can occur when adenine is altered or mismatched with other bases. For example, the deamination of adenine can lead to the formation of hypoxanthine, which can pair with cytosine instead of ...

ADA2, previously known for its role in catalyzing the deamination of adenosine to inosine, is revealed to function as an intracellular DNA-binding protein that controls TLR9 activation in ...