deamination, is about twice as likely to happen when a cytosine is chemically tagged by the addition of a molecule known as a methyl group to create 5-methylcytosine, which occurs in DNA at so ...

Cells employ an arsenal of editing mechanisms to correct mistakes made during DNA replication. How do they work, and what happens when these systems fail?

For example, the deamination of adenine can lead to the formation of hypoxanthine, which can pair with cytosine instead of thymine, resulting in a point mutation. Cells have evolved various DNA repair ...