In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels ...

These receptors are collectively called 'scavenger ... where it must be transported to the liver and secreted in the bile. Since the function of LDL is to carry cholesterol from the liver to ...

E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Cholesterol levels are also controlled by a negative feedback system: cells have LDL receptors on their surface which allow cholesterol to be deposited inside the cells by LDLs once there is an ...

These receptors are collectively called 'scavenger ... where it must be transported to the liver and secreted in the bile. Since the function of LDL is to carry cholesterol from the liver to ...

Study deciphers the molecular handshake between LDL receptors and apoB100 ... Disruptions in LDLR function or apoB100 mutations, as seen in FH, lead to low-density lipoprotein cholesterol ...