E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Researchers developed an epigenetic editing approach to silence the PCSK9 gene, achieving long-term cholesterol reduction ...

Study deciphers the molecular handshake between LDL receptors and apoB100 ... Disruptions in LDLR function or apoB100 mutations, as seen in FH, lead to low-density lipoprotein cholesterol ...

These receptors are collectively called 'scavenger ... where it must be transported to the liver and secreted in the bile. Since the function of LDL is to carry cholesterol from the liver to ...

Dimers of LDL particles connected by a pair of receptors are also visualized for the first time. These studies provide key structural insights into the molecular defects linked to familial ...

Cholesterol levels are also controlled by a negative feedback system: cells have LDL receptors on their surface which allow cholesterol to be deposited inside the cells by LDLs once there is an ...