A research group led by Wei Li at the Chinese Academy of Sciences has created mice born from two male parents and capable of ...

It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.

geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted. The term "knockout mouse" may at first conjure images of a mouse boxing ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

New study reveals that TLE6 protein deficiency causes male infertility in mice. These findings suggest potential genetic ...

Scientists uncover how Ffar4 regulates sugar cravings through gut microbiota, revealing pantothenate as a key mediator to curb sugar intake.