DNA sequencing is a laboratory method used to determine the sequence of a DNA molecule. The method was developed by Frederick Sanger in 1975, who was later awarded the Nobel Prize in chemistry in ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

"Today, the diagnostic yield of genetic sequencing is frustratingly low," Paten said. "One likely cause is the incomplete sequencing methods used in clinical practice. In this work, we test the ...

Thermo Fisher Scientific, Horizon Discovery, OriGene Technologies, QIAGEN, and GeneCopoeia Lead the Competition MicroRNA ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

The gold standard technology that scientists use to detect DNA methylation is bisulfite genomic sequencing. It is a qualitative, quantitative, and efficient approach to identify methylated cytosine at ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

In this study, we used wild-type and TTP-knockout mice to explore ... we employed RNA sequencing (RNA-seq) to assess global gene expression and SLAM-seq to examine mRNA stability.

Additionally, RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were utilized.