To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid ...

One way to understand the function of a gene is to observe a biological system that lacks that gene. But what is the best system to use? When studying human genes, researchers typically employ ...

Thermo Fisher Scientific, Horizon Discovery, OriGene Technologies, QIAGEN, and GeneCopoeia Lead the Competition MicroRNA ...

The human genome consists of three billion base pairs that encode some 100,000 to 300,000 genes. Could we work out all the sequence of this DNA? What use would that information be? The sequence alone ...

Biology has yet to tap into the full benefits of computer simulations, but a new AI foundation model developed by a team of scientists including CMU's Eric Xing hopes to change that.

Genetic changes have the ability to alter crop characteristics, and some crop breeding techniques take advantage of this.

The gold standard technology that scientists use to detect DNA methylation is bisulfite genomic sequencing. It is a qualitative, quantitative, and efficient approach to identify methylated cytosine at ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Homology sequence analysis indicated that Martre1 belongs to a previously under-explored gene family, now designated the Martre gene family. By constructing a mouse model with a complete knockout ...

"Today, the diagnostic yield of genetic sequencing is frustratingly low," Paten said. "One likely cause is the incomplete sequencing methods used in clinical practice. In this work, we test the ...