Without the second gene copy to worry about, we can generate these knockout cell lines in a fairly streamlined and convenient fashion — and we can hit pretty much any gene in the genome.

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

Genes encode proteins and proteins dictate cell ... sites on prokaryotic DNA are typically located close to transcription promoter sites — and this plays an important part in gene expression.