The 5′ cap structure and length of the RNAs are key ... It seems that the complexes are assembled as inactive pre-RNPs on nascent guide RNA transcripts at the genes. The pre-RNPs are transported ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

Early efforts determined the activities of yeast and human exosomes and the structure of the human eukaryotic nine-subunit exosome core. Our investigations of exosomes in budding yeast revealed that ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

For discussion questions and lesson plans, go to the RNA Lab collection on PBS LearningMedia. The standards-based NOVA RNA Lab allows users to explore the science of RNA and learn how to design ...

Researchers have now uncovered the 3D structure of the RNA enzyme SAMURI. Their study provides insights into the development of ribozymes and the evolution of catalytically active RNA. Researchers ...

No large RNA structure database exists that correlates sequence with 3D topology. Successful protein-centric methods like AlphaFold remain unavailable for RNA, creating a critical gap in ...

Enzymes made of RNA are called “ribozymes”. A group of researchers led by Professor Claudia Höbartner at the University of Würburg (JMU) has now uncovered the three-dimensional structure of ...

The integration of high-throughput sequencing technologies, bioinformatics tools, and structural biology approaches will provide a more comprehensive understanding of the complex interplay between RNA ...

What if you could create a molecular machine that might one day help save someone’s life—just by playing a game? Well, you actually can. NOVA’s RNA Lab is an extension of a game called ...

The chemical structure of uracil, showing its single-ring pyrimidine structure. Uracil forms hydrogen bonds with adenine in RNA, contributing to the molecule's structure and function. (Image: Public ...