Helicases and nucleic acid translocases are motor proteins that have essential roles in nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin remodelling.

that requires us to understand the molecular architecture of DNA helicase. Coordination of DNA Unwinding and Replication is Essential Why is coordination between DNA unwinding and synthesis important?

In previous work, using the reconstituted DNA replication system, we have identified the molecular functions for the effector kinase, Rad53, in controlling fork progression and origin activation by ...