Gene knockout models involve the deliberate ... or nonhomologous end-joining (NHEJ). Historically, homologous recombination ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Deletions and duplications of single-base pairs typically arise during homologous recombination and cause diseases. But what happens when a mutation occurs over multiple genes? Deletions involve ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

The investigation involved a comprehensive approach, including the generation of a Setd2-CD knockin mouse model through homologous recombination ... genes in both Setd2-CD and Setd2 knockout ...