gene knockout and knock-in studies are typically performed on cancer cell lines to investigate the efficacy of an existing ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

Cellular and in vitro biochemical experiments showed ... By constructing a mouse model with a complete knockout of the Martre gene family, the researchers observed delays in early embryonic ...