A research group led by Wei Li at the Chinese Academy of Sciences has created mice born from two male parents and capable of ...

In contrast, knockout mice created by the traditional tack of introducing strings of DNA with the desired sequence into ES cells take more than a year to make. Plus, knockouts done with ES cells ...

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein involved in early embryonic development, is known to affect female fertility.

From what draws them in to how to get them out – experts reveal everything you need to know about dealing with mice in the ...

New study reveals that TLE6 protein deficiency causes male infertility in mice. These findings suggest potential genetic ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

Recent work on a full-length knockout in mice falls much more in line with what the community had expected. One group doing the work contains members who had previously contended with the puzzling ...

Researchers explored the role of the TLE6 protein in male fertility using a novel mouse model. TLE6 deficiency caused significant reductions in sperm count and motility and led to abnormal sperm ...