measured the mitochondrial levels of free deoxynucleotide triphosphates (dNTPs), the building blocks of new DNA strands made during DNA replication, in tissues from young and old rats. As shown in ...

Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and mitochondrial DNA replication and repair. A number of projects in the lab address fundamental questions ...

Alexeyev and his collaborators aim to overcome what he calls an interspecies barrier of mitochondrial DNA replication. “That ...

More information: Mitochondrial DNA replication stress enacts an endosomal pathway of nucleoid disposal prone to innate ...