These scientists made the important observation that most of the membrane that was ... they observed that LDL internalization was mediated by a specific receptor present in the surface of the ...

Reduced receptor-mediated catabolism of LDL causes high plasma LDL cholesterol (LDL-C) and premature coronary artery disease. Statins lower plasma cholesterol by upregulating LDL receptor gene ...

PubMed and Scopus databases were searched to retrieve clinical trials on the efficacy and/or safety of novel LDL-C-lowering agents including PCSK9 inhibitors, mipomersen (Kynmaro®), lomitapide ...