pharmacological inhibitors or gene mutants should be used to confirm data from siRNA-mediated knockdown. The final word in target validation is to reintroduce an RNAi-resistant version of the ...

One of the worries with RNAi experiments is that siRNAs might knock down or induce genes other than the intended target. For example, an siRNAs “may be perfectly complementary to a gene but also ...

Functional genomics can help deconvolute the link between genotype and phenotype in disease, revealing new drug targets and ...

Arrowhead Pharmaceuticals, Inc. (NASDAQ: ARWR) today announced that it will host a webcast and conference call on February 10, 2025, at 4:30 p.m. ET to discuss its financial results for the fiscal ...

Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that ...