During DNA replication, the unwinding of strands leaves ... effective approach is to find proteins that directly bind to both enzymes. However, that requires us to understand the molecular ...

Cells employ an arsenal of editing mechanisms to correct mistakes made during DNA replication. How do they work, and what happens when these systems fail?

“This study reveals that this enzyme [nSMase2] is such an enzyme that the virus has evidently hijacked to use in its replication strategy.” Previous research suggested that HIV infection increased the ...

The repair enzymes are remarkably conserved from bacteria to fungi to humans, underscoring the premium placed on maintaining genomic integrity in the face of a mutagenic burden. DNA is susceptible to ...

APOBEC enzymes, which normally help fight viral infections by mutating viral DNA, cause repeat expansions and are unusually ...

Research into a chemical compound that shows promise in stopping COVID-19 involved five nat'l labs and others, but led by Oak ...