The chromatin landscape is a key aspect of epigenetic regulation in eukaryotes. Old histones are recycled during DNA replication, therefore providing a blueprint for the duplication of their ...

At non-telomeric sites, chromatin is assembled during S-phase when chromatin remodelling factors and histone chaperones disassemble nucleosomes in front of the replication fork and reassemble them on ...

It is therefore important for cells to have means of opening up chromatin fibers and/or removing histones transiently to permit transcription and replication to proceed. Generally speaking ...

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. One fundamental question is: how do replication forks efficiently progress through chromatin?

We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides ...

Antonio Bedalov studies chromatin, the material that makes up the chromosomes of humans and other ... First, he studies how cells regulate the transcription and replication of repetitive DNA sequences ...

Combining long-read DNA sequencing with a predictive artificial intelligence model has provided new insights into DNA ...