The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP) enzyme responsible for copying DNA into RNA can generate rampant R-loops—if not for the intervention of a ...

Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks ...

The jaws of life All living things rely on RNAP to transcribe DNA into RNA. In bacteria, researchers have long known that transcription begins when RNAP clamps onto a DNA strand and initiates the ...