现在，《自然结构与分子生物学》杂志上的一项新研究描述了RapA酶如何阻止大肠杆菌中r环的形成，这对所有细胞如何保持基因组稳定性具有深远的意义。研究结果表明，在某些情况下，负责将DNA复制成RNA的RNA聚合酶（RNAP）可以产生猖獗的r -环——如果没有一种叫做RapA的蛋白质的干预的话。

Crystal structures of Mtb RNAP bound to rifampin (left) and Mtb RNAP bound to an AAP (right) show the Mtb RNAP interactions. Gray ribbons, Mtb RNAP backbone; gray, cyan, and green sticks ...

The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP) enzyme responsible for copying DNA into RNA can generate rampant R-loops—if not for the intervention of a ...

The jaws of life All living things rely on RNAP to transcribe DNA into RNA. In bacteria, researchers have long known that transcription begins when RNAP clamps onto a DNA strand and initiates the ...