In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, ...

Expression of sphingomyelin synthase 1 (SMS1), an enzyme that generates sphingomyelin (SM) and diacylglycerol (DAG) from de novo-synthesised ceramide, was increased in the liver of multiple murine ...

FRONT PHARMACOL. 2022 2022/1/20;13:969408. [2] Luan H, Chen S, Zhao L, Liu S, Luan T. Precise Lipidomics Decipher Circulating Ceramide and Sphingomyelin Cycle Associated with the Progression of ...

Metabolomic and lipidomic analyses of SMT indicated that HT promotes ceramide breakdown, leading to an increase in sphingomyelin and sphingosine. Further investigation revealed that the ...