Consequently, lactate dehydrogenase inhibitors may represent effective targets for inhibiting tumor progression. Such inhibitors have been proven to alleviate the harmful neutrophil mobilization ...

New research published in Cancer Cell suggests that tumour-associated neutrophils can have antitumorigenic ('N1') or protumorigenic ('N2') functions, a plasticity that has been well described for ...

The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute to colorectal cancer (CRC) metastasis. We investigated the cellular source for secreted AGR2 in the TME and ...

Notably, within myeloid cell-enriched TIME subtype, tumor-associated neutrophil (TAN) populations were significantly associated with unfavorable prognosis. By in vitro induction of TANs and ex vivo ...

where they can either promote or inhibit cancer growth. This dual functionality suggests that neutrophils are highly plastic, with their actions shaped by dynamic environmental cues within the ...

Here, we show that neutrophils express among others Siglec-9 ... We employed antibodies of IgG1 or IgG2 isotypes against the tumor associated antigens EGFR and HER2 to demonstrate that sialic acid ...

Medically reviewed by Douglas A. Nelson, MD While a persistent, low-grade fever can occur with many different types of cancer ...

Previous studies showed that tumors are associated with the increased inflammatory burden and neutrophil-to-lymphocyte ratio (NLR) is also associated with inflammatory conditions. However, there is no ...

Prior studies in both animals and humans have reported that neutrophils can cross the blood-brain barrier, and although these cells are not typically attracted to glioblastomas, they are recruited at ...

Bin Gao and his colleagues at the National Institutes of Health provide an in-depth analysis of IL-8 + neutrophils, which are implicated as central drivers of the inflammation associated with sAH.