We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...

DSBs and DNA Rearrangements in Cancer Cells Together with a variety of other molecules, ATR and ATM kinases are key factors for the surveillance of DNA replication, and prevent chromosome breakage ...

Chromosome Dynamics: Although genetic information is encoded in a one-dimensional array of DNA bases, all major DNA processes (replication, transcription and recombination) are controlled by changes ...

Their work clarified the relationship between cell composition and growth rate and led to unravel the temporal coupling between chromosome replication and the subsequent cell division by Helmstetter ...

The new finding is published in Cell in an article titled, “ SMC motor proteins extrude DNA asymmetrically and can switch directions ,” and is key to understanding how these motors shape our genome ...

Each cell with a nucleus contains chromosomes, which are made from DNA Human body cells each contain 23 pairs of chromosomes, half of which are from each parent. So, human gametes (eggs and sperm ...

A single strand of DNA forms a chromosome, like the one displayed to the left. This chromosome is magnified (1000x). That's not nearly enough to show a single strand of DNA, which is only wide ...

The nucleus of each human body cell contains 46 chromosomes. Each chromosome contains about 1000 genes. There is enough DNA in all the cells in a human body to stretch to the sun and back again ...

(B) If adult stem cells underwent random chromosome segregation, all chromosomes would assort with equal frequency to either stem cells or their differentiating sisters (squares) (B). Matthew Meselson ...

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...

Human chromosomes are constantly assaulted by challenges to their integrity as a result ... DSBs arise from agents, such as ionizing radiation, and can also occur spontaneously during DNA replication.