Furthermore, telomere shortening due to the inability of the DNA-replication machinery to fully replicate the ends is a critical mechanism of tumor suppression as well as a hallmark of aging.

Helicases and nucleic acid translocases are motor proteins that have essential roles in nearly all aspects of nucleic acid metabolism, ranging from DNA replication to chromatin remodelling.

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...

Carol Greider and Elizabeth Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes ... This experiment showed that the ...

The activation of telomerase in the cells of inner cells mass is a crucial step ... The G-richness and highly repetitive nature of telomeric DNA pose major challenges to the DNA replication machinery.

We examine a variety of DNA polymerases including human DNA polymerases and telomerase; eubacterial and archaeal DNA polymerases; and viral replicases and reverse transcriptases. The work addresses ...