Stress affects the function of PD-L2-positive macrophages by disrupting the activity of the β2-adrenergic receptor (Adrb2). Macrophages that develop after the disruption of Adrb2 showed reduced ...

However, the study reveals that psychological stress affects their function by disrupting the activity of the β2-adrenergic receptor (Adrb2) activity. Macrophages that mature under this altered ...

Stress also leads to SNS release of norepinephrine acting on Adrb2 on monocytes and PD-L2 + macrophages. The reduction in efferocytosis-related gene expression causes dead cell accumulation in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Pro-inflammatory macrophage activation is a ...

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing ...

1Department of Medicine, Columbia Center for Human Development, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York. 2Herbert Irving Comprehensive ...

1Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center Columbia University Medical Center, New York, New York. 2Columbia University Digestive and Liver ...