Western blot analysis was performed to examine the components of the PI3K/AKT signaling pathway. Results: Among the sixty-four shared targets identified, JUN and CCND1 were the most frequently ...
qRT-PCR was used to detect other relative gene expressions that were closely related with SM mass. The activity of insulin-like growth factor-1 (IGF-1)/protein kinase B (PKB/AKT) pathway in SM was ...
Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in prostate cancer. Although the most common mutation, in a gene called Pten, ...
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...