A study published by the Journal of Traditional and Complementary Medicine and e-published by the U.S. National Library of ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

产品活性：Capivasertib (AZD5363) 是一种口服有效的 pan-AKT 激酶抑制剂，抑制 Akt1，Akt2 和 Akt3，IC50 分别为 3，7 和 7 nM。 体外：Capivasertib 是一种新型吡咯并嘧啶衍生化合物，可抑制所有 AKT 亚型，效力为 10 nM 或更低。Capivasertib 可抑制这些底物的磷酸化，在 3 种细胞系 ...

Western blot analysis was performed to examine the components of the PI3K/AKT signaling pathway. Results: Among the sixty-four shared targets identified, JUN and CCND1 were the most frequently ...

Autophagy counterbalances cellular stress associated with oncogenic KRAS activation, as do specific metabolic and reactive oxygen species detoxifying adaptions that represent acquired vulnerabilities.

Moreover, the downstream regulation of HOXA10-AS primarily occurs through the activation of multiple signaling pathways (Figure 7). HOXA10-AS is involved in cancer progression through the activation ...