阿尔茨海默病的发生主要是因为大脑中β-淀粉样蛋白（Aβ）和Tau这两种蛋白的异常沉积导致了神经元死亡和一系列病理，而载脂蛋白E（ApoE）又是脑部运输Aβ和Tau最关键的蛋白，影响阿尔茨海默病的发展。 “我们研究发现，ApoE3 R136S这个突变蛋白和Tau有很强的 ...

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.

Moreover, the differential use of two canonical receptors and the presence of non-canonical receptors and co-receptors add to the functional diversity of Reelin. In this review, I summarize recent ...

Once every four weeks maintenance dosing may be easier for patients and care partners to continue treatmentAlzheimer's disease progression does ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Safety, tolerability, pharmacokinetic, and pharmacodynamic profile supports continued development of VG-3927 as potential once-daily oral ...

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

Alzheimer's disease may be the most common dementia, but amyloid-beta (Aβ) plaques and tau tangles don't tell ... versus sleep is another mechanism. ApoE protein is a lipid-binding protein ...