At late disease stages, mainly HD4, neuronal ALP dysfunction exhibited enlarged/clumped CTSD-immunoreactive autolysosomes (AL)/LY and ultrastructural evidence of autophagic vacuole (AV) fusion and ...

However, the physiological significance of autophagic degradation of the nucleus ... and is delivered to the vacuole. In contrast, in micronucleophagy, the nucleus's outer surface directly ...

MDC staining solution (Sigma) was dissolved in PBS. Adherent cells were incubated with MDC for 30 min at 37°C. After rinsing in washing buffer three times, MDC combined with acidic autophagic vesicles ...

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China ...

Department of Cell and Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, United States Heat Shock Factor 1 (HSF1) is a major transcriptional factor ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Biogenesis of membrane-bound organelles ...

Intracellular lipid transport can occur by flip‐flop from one side of a bilayer to the other, by vesicular trafficking, by lipid transfer proteins, or by diffusion within a bilayer 34. MAMs are hubs ...