This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China ...

LCs were even present in the nose and ears of aged mice. Depending on the location, the stiffness and pliability of cartilage varies. The team wanted to understand how the lipid vacuoles inside LCs ...

Once the autophagic induction has been triggered ... ATG2, which transfers lipid molecules from the ER to form autophagosomes, vacuole membrane protein 1 (VMP1) and transmembrane protein 41b (TMEM41b) ...

MDC, a fluorescent marker of autophagic vacuoles, was used to detect the autophagic activity. BV2 cells were pre-treated with 25 μM BBR with or without 10 mM 3-MA for 3 h, this was followed by ...