CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

With vasa-Cas9, high efficiency and self-limiting suppression was achieved. Applying the CRISPR-Cas9 system to edit high GC content genomes has been challenging due to its high off-target activity.

The study has been published in the journal Nature Biotechnology. Although AZD7648 promotes precise repair and thus precise gene editing using the CRISPR-Cas9 system as hoped, in a significant ...

神经免疫相关研究是科研的热门方向，在调研了一线科研工作者的需求后，我们联系并邀请到了浙江大学研究员侯宇作为讲者对近期一项研究进行分享，分享主题为CRISPR-Cas9 筛选揭示神经-免疫 ...

Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating ...

CRISPR-Cas9技术因其高效的基因编辑能力成为功能基因 ... 为了解决这一难题，12月16日Nature Biotechnology的研究报道“CRISPR-StAR enables high-resolution genetic screening in complex in vivo models”，研究人员开发 ...

这项发表在《自然》杂志上的研究利用CRISPR-Cas9基因编辑技术分析了近7000种BRCA2变异的功能影响，最终确定了那些增加癌症风险的变异和那些不会增加癌症风险的变异。这一新信息将消除围绕VUS ...

Australian cancer researchers are the first to establish a next-generation gene-editing tool for modelling and interrogating human disease.

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

在Nature发表了题为Neuropeptide signaling orchestrates T cell differentiation 的论文。本研究利用了小鼠体内以及体外的CRISPR-Cas9筛选系统，筛选了调节CD4+ T细胞 ...