Cell-cycle exit is correlated with a decrease in cyclin-dependent kinase (CDK) activity. The molecular mechanisms by which differentiation and CDK activity interconnect are poorly understood.

CDKN1B 5′UTR mediates its cell cycle-dependent translation and ... MAP2K (also known as MEK), BCR-ABL and SRC. The cyclin-dependent kinase (Cdk) inhibitor p27 (also known as KIP1) regulates ...

"This paper describes the identification and characterization of the first human gene encoding a protein- p21Cip1-which functions to negatively regulate Cdks controlling cell-cycle entry," remarks ...

Cyclins regulate steroid receptor action in cyclin-dependent kinase (CDK)-dependent and independent manners. In addition to regulating the cell cycle, cyclin A2 (CCNA2) also mediates female sex ...

Cdks and cyclins form complexes whose intrinsic kinase activities enable cell-cycle transitions at G1/S and G2/M. Kaldis' team generated Cdk2/Cdk4 double knockout mice, which die at embryonic day 15 ...

Cyclin-dependent kinase enzymes (CDKs) are of two types: cell cycle-regulating CDKs that participate in the progression of the cell cycle and transcriptional ones that control gene expression.

My laboratory has combined biochemical, molecular, cellular, and genetic approaches to investigate the roles of CDK inhibitors in differentiation ... ATRX in senescence provides new insight for ...