A key target of the APC is securin, the destruction of which initiates chromosome segregation by unleashing the protease separase, which destroys sister-chromatid cohesion. The APC also ...

The targeting of telomeres offers promise for new cancer therapies, which can be aimed at disrupting the mechanisms that ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chromosome segregation relies on kinetochores ...

The wide variety of congenital anomalies often accompanying constitutional aplastic anemia has led to its recognition as a distinctive syndrome. Congenital malformations have been the outstanding ...

This month's cover highlights the article The Dystrophin-Dystroglycan complex ensures cytokinesis efficiency in Drosophila epithelia by Eurico Morais-de-Sá, Margarida Gonçalves and colleagues. The ...