Cyclin-dependent kinases (CDKs ... on the basis of similarities in sequence and function as described below. This nomenclature will facilitate the rational and comparative study of the poorly ...

Cyclin destruction can order late mitotic events. What function is served by destroying ... reveal a broad range of activities (L. Holt and D.O.M., unpublished observations), and some Cdk targets ...

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Injecting infarcted pig hearts with specially bioengineered cells significantly decreased the infarct area and improved heart function, showing possible clinical ... led by Jianyi “Jay” Zhang, M.D., ...

Taking High-Dose Vitamin D Supplements for Five Years Did Not Affect ... Vitamin K Prevents Cell Death: New Function for a Long-Known Molecule Aug. 3, 2022 — Researchers report on a novel ...

Acute respiratory distress syndrome (ARDS) is a neutrophil-dominant disorder with no effective pharmacological therapies. While the cyclin-dependent kinase inhibitor AT7519 induces neutrophil ...

Shun Chi Sun Laboratory for Traditional Chinese Medicine Research, Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China Correspondence: Dr. Louis W.C. Chow, Department of Surgery, ...

The current study advances a 2021 study by Zhang and colleagues that showed heart attack recovery could be aided by injection of heart muscle cells that overexpress cyclin D2. However, these ...

Executive function describes a set of cognitive processes and mental skills that help an individual plan, monitor, and successfully execute their goals. The “executive functions,” as they’re ...

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Media ReleaseMarking Immutep’s transition to a Phase III biotech, the Company’s pivotal TACTI-004 trial in first-line non-small cell lung cancer ...