Promoter sequences are DNA sequences that define where transcription of a gene by RNA polymerase begins. Promoter sequences are typically located directly upstream or at the 5' end of the ...

RNA polymerase binds to a region just before the gene, called the promoter, before moving down the DNA to the gene. Enhancers are regions of DNA that act as molecular switches for turning genes on ...

Neuropsychiatric disorders are becoming increasingly prevalent. Given their complex and multifactorial pathogenesis, there is ...

DNA (deoxyribonucleic acid), the molecular "blueprint" carrying the genetic instructions that influence the growth, ...

DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a ...

Many studies have used single-cell RNA sequencing (scRNA-seq) to infer gene regulatory networks (GRNs), which are crucial for ...

New study by Chiba University, Japan in collaboration with Karolinska Institutet, Sweden, uncovers novel enhancer-promoter interactions that regulate gene expression during neuronal differentiation ...

A new study has unveiled the genetic mechanism controlling citric acid content in jujube fruit, identifying a natural ...

This work sheds light on how these elements contribute to cell-specific gene expression and how mutations within them may influence health and disease. CREs, including enhancers and promoters ...

[101] This sequence, which is known to induce DNA curvature, may serve to bring together proteins that bind at sites flanking this motif. Examination of the other insulin promoters reveals that ...