A research group led by Wei Li at the Chinese Academy of Sciences has created mice born from two male parents and capable of ...

It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted. The term "knockout mouse" may at first conjure images of a mouse boxing ...

To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

Scientists uncover how Ffar4 regulates sugar cravings through gut microbiota, revealing pantothenate as a key mediator to curb sugar intake.

New study reveals that TLE6 protein deficiency causes male infertility in mice. These findings suggest potential genetic ...